Targeting GABA signaling in the tumor microenvironment: implications for immune cell regulation and immunotherapy resistance

As an important inhibitory neurotransmitter, γ-aminobutyric acid (GABA) not only plays a key role in the central nervous system, but also has attracted wide attention in the tumor immune microenvironment in recent years. Studies have shown that tumor cells can synthesize GABA and use it to remodel t...

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Bibliographic Details
Main Authors: Yuanqing Zhao, Jin Xu, Ke Yang, Li Bao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1645718/full
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