Promotion of pathological cardiac remodeling by excessive mitochondrial fission in physical inactivity and myocardial infarction

Promotion of pathological cardiac remodeling by excessive mitochondrial fission in physical inactivity and myocardial infarction

Abstract Physical inactivity and sedentary lifestyle, including prolonged sitting, are among the most important modifiable risk factors for morbidity and mortality in myocardial infarction (MI). Recently, mitochondrial dynamics (fusion and fission) have gained considerable attention as imbalanced dy...

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Main Authors: Masashi Miyao, Hikaru Oshima, Chihiro Kawai, Shota Furukawa, Hirokazu Kotani, Hirozo Minami, Hitoshi Abiru, Hideki Nagai, Hiromu Yanagisawa, Koh Ono, Keiji Tamaki, Yoko Nishitani
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Coronary artery disease
Metabolic syndrome
Mitochondrial dynamics
Mitochondrial dysfunction
Sedentary lifestyle
Online Access:https://doi.org/10.1038/s41598-025-10373-8
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https://doi.org/10.1038/s41598-025-10373-8

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