Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Abstract Circulating tumor cells (CTCs) and their clusters are the cellular drivers of metastasis. This study uses microfluidic models mimicking human capillary bifurcations to better understand how these cells interact with capillary beds. Patient CTCs, CTC‐derived explant cells, and numerous cance...

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Main Authors: Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
cancer metastasis
circulating tumor cells
large extracellular vesicles
premetastatic niche
microfluidics
Online Access:https://doi.org/10.1002/advs.202506339
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https://doi.org/10.1002/advs.202506339

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