Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants.

Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants.

<h4>Background</h4>Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible. For an effective immune prophylaxis in humans, broad coverage of different strains of SARS-CoV...

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Main Authors: Jan ter Meulen, Edward N van den Brink, Leo L M Poon, Wilfred E Marissen, Cynthia S W Leung, Freek Cox, Chung Y Cheung, Arjen Q Bakker, Johannes A Bogaards, Els van Deventer, Wolfgang Preiser, Hans Wilhelm Doerr, Vincent T Chow, John de Kruif, Joseph S M Peiris, Jaap Goudsmit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-07-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0030237&type=printable
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https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0030237&type=printable

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