G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation

G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation

Aims: Oestrogen drives long-bone development through various oestrogen receptors. G-protein-coupled oestrogen receptor-1 (GPER-1), a membrane oestrogen receptor, mediates longitudinal bone growth during early puberty; however, the underlying mechanisms remain unclear. Therefore, this study elucidate...

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Bibliographic Details
Main Authors: Ya-Shuan Chou, Sung-Yen Lin, Shu-Chun Chuang, Pei-Yin Shih, Chung-Hwan Chen, Mei-Ling Ho, Je-Ken Chang
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-07-01
Series:Bone & Joint Research
Subjects:
gper-1
estrogen receptor
longitudinal bone growth
growth plate chondrocyte
pthrp/ihh regulation
growth plates
chondrocytes
oestrogen
pthrp
collagen
staining
long-bone
agonist
bone growth
col2a1
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.147.BJR-2024-0347.R1
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https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.147.BJR-2024-0347.R1

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