Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?

Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?

A-kinase anchoring protein 79/150 (AKAP79/150) is a crucial scaffolding protein that positions various proteins at specific synaptic sites to modulate excitatory synaptic intensity. As our understanding of AKAP79/150's biology deepens, along with its significant role in the pathophysiology of v...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen-Chao Chu, Ya-Hui Hu, Gui-Zhou Li, Jiang Chen, Ning-Ning Zhang, Yi-Xue Gu, Shi-Yu Wu, Hai-Feng Zhang, Yang-Yang Xu, Hong-Li Guo, Xin Tian, Feng Chen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
Subjects:
AKAP79/150
Structure and biological functions
Inflammatory pain
Epilepsy
Depression
Potential therapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000282
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A-kinase anchoring protein 79/150 (AKAP79/150) is a crucial scaffolding protein that positions various proteins at specific synaptic sites to modulate excitatory synaptic intensity. As our understanding of AKAP79/150's biology deepens, along with its significant role in the pathophysiology of various human disorders, there is growing evidence that reveals new opportunities for therapeutic interventions. In this review, we examine the fundamental structure and primary functions of AKAP79/150, emphasizing its pathophysiological mechanisms in different nervous system disorders, particularly inflammatory pain, epilepsy, depression, and Alzheimer's disease. We also discuss its potential therapeutic implications for patients suffering from these conditions.
ISSN:1095-953X

Similar Items