Disruption of oncogenic MCL-1-BAX/BAK interaction using integrase inhibitors: insights from a molecular docking and dynamic exploration

Disruption of oncogenic MCL-1-BAX/BAK interaction using integrase inhibitors: insights from a molecular docking and dynamic exploration

Abstract Myeloid cell leukemia-1 (MCL-1) is a prominent representative of the BCL-2 antiapoptotic protein family and plays a key role in the dysregulation of programmed cell death. Overexpression of MCL-1 has emerged as a survival and drug resistance mechanism in several malignancies. Currently, the...

Full description

Saved in:
Bibliographic Details
Main Authors: Lateef O. Anifowose, Fikayo N. Adegboyega, Oludare M. Ogunyemi, Rukayat O. Akano, Oluwatoyin A. Adeyemo-Salami, Sherif F. Hammad, Mohamed A. Ghazy
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Chemistry
Subjects:
MCL-1
Bictegravir
BCL-2
Cabotegravir
Inhibitors
Cancer
Online Access:https://doi.org/10.1007/s44371-025-00222-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1007/s44371-025-00222-y

Similar Items