CD28 signaling domain boosts persistence and in vivo anti-tumor activity of stem cell-derived CD19-CAR-NK cells

CD28 signaling domain boosts persistence and in vivo anti-tumor activity of stem cell-derived CD19-CAR-NK cells

Summary: Allogeneic natural killer (NK) cell-based therapies with an outstanding safety profile, are a compelling alternative to autologous T cell-based approaches for cancer immunotherapy, offering innate tumor-killing ability that can be further augmented via introduction of tumor antigen-specific...

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Bibliographic Details
Main Authors: Nina Kok, Didem Ozkazanc, Amanda A. van Vliet, Danielle Steenmans, Simar Pal Singh, Tolga Sutlu, Anna-Maria Georgoudaki, Monica Raimo, Jan Spanholtz, Adil Doganay Duru
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Immunology
Systems biology
Cancer systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008090
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http://www.sciencedirect.com/science/article/pii/S2589004225008090

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