The Sdp-SH3b2 domain contained in Lactobacillus johnsonii N6.2-derived extracellular vesicles inhibit murine norovirus replication

The Sdp-SH3b2 domain contained in Lactobacillus johnsonii N6.2-derived extracellular vesicles inhibit murine norovirus replication

The internalization of Lactobacillus johnsonii N6.2 extracellular vesicles (EVs) by cells results in a significant induction of the 2’,5’-oligoadenylate synthetase (OAS) pathway. It also induces expression of IFI44L, MX1, MX2 and DDX60. In this work, we evaluated whether the antiviral response induc...

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Bibliographic Details
Main Authors: Danilo R. da Silva, Asra B. Sharjeel, Reagan Beliakoff, Leandro D. Teixeira, Peter E. Kima, Melissa K. Jones, Claudio F. Gonzalez, Graciela L. Lorca
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
Lactobacillus johnsonii N6.2
probiotic
MNV-1
bacterial effector
extracellular vesicle
SH3b
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490755/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490755/full

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