Isolation of Allosteric Tryptase Inhibitor from Methanol Extract of Rhubarb and Enhancement of Its Tryptase Inhibitory Activity by Compounds That Were Screened by In Silico Screening

Isolation of Allosteric Tryptase Inhibitor from Methanol Extract of Rhubarb and Enhancement of Its Tryptase Inhibitory Activity by Compounds That Were Screened by In Silico Screening

Tryptase, which is abundant in human mast cells and is involved in allergic inflammations such as asthma, is a serine protease. We isolated a tryptase inhibitor, procyanidin B8 3,3′-di-<i>O</i>-gallate (PB8GG’), a tannin, from the methanol extract of rhubarb (RHEI RHIDOMA), which is a tr...

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Bibliographic Details
Main Authors: Hidetoshi Fujii, Moeno Ito, Kentaro Nishioka, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Takashi Tanaka, Masaya Nagao
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Molecules
Subjects:
tryptase
allosteric inhibitor
rhubarb
tannin
in silico screening
Online Access:https://www.mdpi.com/1420-3049/30/6/1341
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