A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma.

A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma.

Gastric mucosa-associated lymphoid tissue (MALT) lymphomas develop from a chronic Helicobacter infection. Phospholipase C gamma 2 (PLCG2) is important for B-cell survival and proliferation. We used BALB/c mice with a gain-of-function mutation in the Plcg2 gene (Ali5) to analyze its role in the devel...

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Main Authors: Jennifer Gossmann, Manfred Stolte, Michael Lohoff, Philipp Yu, Roland Moll, Florian Finkernagel, Holger Garn, Cornelia Brendel, Alwina Bittner, Andreas Neubauer, Minh Q Huynh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0150411&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0150411&type=printable

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