Oestrogen suppresses the adipogenesis of fibro/adipogenic progenitors through reactivating the METTL3–ESR1‐mediated loop in post‐menopausal females

Oestrogen suppresses the adipogenesis of fibro/adipogenic progenitors through reactivating the METTL3–ESR1‐mediated loop in post‐menopausal females

Abstract Background Post‐menopausal women experience more severe muscular fatty infiltration, though the mechanisms remain unclear. The decline in estrogen levels is considered as a critical physiological alteration during post‐menopause. Fibro/adipogenic progenitors (FAPs) are identified as major c...

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Main Authors: Hao Zhou, Shujing Feng, Jinkui Cai, Xiexiang Shao, Siyuan Zhu, Han Zhou, Yongmin Cao, Ru Wang, Xingzuan Lin, Jianhua Wang
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Subjects:
adipogenesis
ESR1
fibro/adipogenic progenitors (FAPs)
m6A methylation
METTL3
muscular fatty infiltration
Online Access:https://doi.org/10.1002/ctm2.70206
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https://doi.org/10.1002/ctm2.70206

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