Evolving genomic landscape of pediatric pneumococcus in two Canadian urban centers following conjugate vaccination

Evolving genomic landscape of pediatric pneumococcus in two Canadian urban centers following conjugate vaccination

Background and aimPneumococcal conjugate vaccines (PCVs) have significantly reduced pediatric invasive pneumococcal disease (IPD). However, vaccine escape variants, the emergence of non-vaccine serotypes (NVTs), and antimicrobial resistance (AMR) remain ongoing concerns. We aimed to characterize lon...

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Bibliographic Details
Main Authors: Sarah Teatero, Allison McGeer, Agron Plevneshi, Leah J. Ricketson, James D. Kellner, Nahuel Fittipaldi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
Streptococcus pneumoniae
pneumococcal conjugate vaccine (PCV)
serotype replacement
antimicrobial resistance
whole-genome sequencing
genomic epidemiology
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1642658/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1642658/full

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