Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions

Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions

Expansion of CGG repeats (CGGexp) in the 5’ untranslated region (5’UTR) of the FMR1 gene underlies the fragile X premutation-associated conditions including tremor/ataxia syndrome, a late-onset neurodegenerative disease and fragile X-associated primary ovarian insufficiency. One common pathomechanis...

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Bibliographic Details
Main Authors: Katarzyna Tutak, Izabela Broniarek, Andrzej Zielezinski, Daria Niewiadomska, Tomasz Skrzypczak, Anna Baud, Krzysztof Sobczak
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
FMR1
unstable CGG repeats
expansion of triplet repeats
polyglycine
ribosomal heterogeneity
near-cognate start codon
Online Access:https://elifesciences.org/articles/98631
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https://elifesciences.org/articles/98631

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