Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients

Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients

AmisChemotherapy-induced hepatotoxicity (CIH) is a significant concern in colorectal cancer (CRC) patients treated with the CAPEOX (capecitabine and oxaliplatin) regimen. Identifying predictive factors for CIH is crucial for clinical management.Patients and MethodsThis study analyzed colorectal tiss...

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Main Authors: Huilin Xu, Mingming Li, Houshan Yao, Guoliang Chen, Jiani Chen, Xinyun Hou, Hong Yang, Chenghang Yu, Zeshuai Lin, Jiawei Zhu, Rong Wang, Shi Qiu, Xuan Liu, Zhipeng Wang, Xia Tao, Lei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
chemotherapy-induced hepatotoxicity
multi-omics analysis
capeox
endogenous susceptible biomarkers
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1517446/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1517446/full

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