Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts

Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts

Abstract Several in-silico methods emerge to assess HLA immunogenicity and stratify immunological risk, including HLA molecular mismatches and HLA evolutionary divergence (HED). However, their added value in risk-stratifying antibody-mediated rejection (AMR) remains uncertain. We include 5159 kidney...

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Main Authors: Zeynep Demir, Marc Raynaud, Gillian Divard, Kevin Louis, Agathe Truchot, Matthias Niemann, Renata Ponsirenas, Olivier Aubert, Arnaud Del Bello, Alexandre Hertig, Dany Anglicheau, Bethany Dale, Nassim Kamar, Massimo Mangiola, Adriana Zeevi, Carmen Lefaucheur, Alexandre Loupy
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60485-y
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https://doi.org/10.1038/s41467-025-60485-y

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