Granzyme B+ CD4 T cells accumulate in the colon during chronic HIV-1 infection

Granzyme B+ CD4 T cells accumulate in the colon during chronic HIV-1 infection

Chronic HIV-1 infection results in the sustained disruption of gut homeostasis culminating in alterations in microbial communities (dysbiosis) and increased microbial translocation. Major questions remain on how interactions between translocating microbes and gut immune cells impact HIV-1-associated...

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Bibliographic Details
Main Authors: Stephanie M. Dillon, Kaylee L. Mickens, Tezha A. Thompson, Emily H. Cooper, Sabrina Nesladek, Allison J. Christians, Moriah Castleman, Kejun Guo, Cheyret Wood, Daniel N. Frank, Katerina Kechris, Mario L. Santiago, Cara C. Wilson
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
HIV
gut
CD4 T cells
dysbiosis
granzyme B
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2045852
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https://www.tandfonline.com/doi/10.1080/19490976.2022.2045852

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