NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss

NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss

ABSTRACT This study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function. We also explored the role of NPC1L1 in osteoporosis (OP), focusing on the downstream C/EBPα/Cyp27a1/27‐hydroxycholester...

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Bibliographic Details
Main Authors: Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:FASEB BioAdvances
Subjects:
27‐hydroxycholesterol
cholesterol metabolism
NPC1L1
osteogenic differentiation
osteoporosis
Online Access:https://doi.org/10.1096/fba.2025-00044
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https://doi.org/10.1096/fba.2025-00044

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