Rationale and design of a large trial of perioperative ketamine for prevention of chronic post-surgical pain
Abstract Background Chronic post-surgical pain (CPSP) is recognised as one of the most common and debilitating complications of major surgery. Progression from acute to chronic pain after surgery involves sensitisation of central nervous system pathways with the N-methyl-D-aspartate (NMDA) receptor...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
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| Series: | Trials |
| Online Access: | https://doi.org/10.1186/s13063-024-08672-y |
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