APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses

Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accumulation remain unclear. Apolipoprotein E (ApoE) is a droplet-associated protein, and its E4 variant confers the greatest genetic risk for late-on...

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Bibliographic Details
Main Authors: Cassi M. Friday, Isaiah O. Stephens, Cathryn T. Smith, Sangderk Lee, Diksha Satish, Nicholas A. Devanney, Sarah Cohen, Josh M. Morganti, Scott M. Gordon, Lance A. Johnson
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neurobiology of Disease
Subjects:
Apolipoprotein E4
APOE4
Lipid droplets
Microglia
Neuroinflammation
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001998
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http://www.sciencedirect.com/science/article/pii/S0969996125001998

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