Effects of 5-Methyl-2′-Deoxycytidine in G-Quadruplex Forming Aptamers d(G<sub>3</sub>C)<sub>4</sub> and d[GCG<sub>2</sub>(CG<sub>3</sub>)<sub>3</sub>C]: Investigating the Key Role of the Loops

Effects of 5-Methyl-2′-Deoxycytidine in G-Quadruplex Forming Aptamers d(G<sub>3</sub>C)<sub>4</sub> and d[GCG<sub>2</sub>(CG<sub>3</sub>)<sub>3</sub>C]: Investigating the Key Role of the Loops

T40214 (STAT) and its recently investigated analogue STATB are G-quadruplex (G4) forming aptamers characterized by an unusually high percentage of C. The therapeutic potential of T40214 relies on its ability to inhibit the signalling pathway of STAT3, a protein frequently overexpressed in tumor cell...

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Bibliographic Details
Main Authors: Veronica Esposito, Daniela Benigno, Carla Aliberti, Camilla Esposito, Elisabetta Panza, Antonella Virgilio, Aldo Galeone
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
aptamers
G-quadruplex
5-methyl-2′-deoxycytidine
antiproliferative activity
Online Access:https://www.mdpi.com/2218-273X/15/6/753
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