A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets.

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets.

Over the past 20 years, 3 highly pathogenic human coronaviruses (HCoVs) have emerged-Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and, most recently, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-demonstrating that...

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Main Authors: Annika Kratzel, Jenna N Kelly, Philip V'kovski, Jasmine Portmann, Yannick Brüggemann, Daniel Todt, Nadine Ebert, Neeta Shrestha, Philippe Plattet, Claudia A Staab-Weijnitz, Albrecht von Brunn, Eike Steinmann, Ronald Dijkman, Gert Zimmer, Stephanie Pfaender, Volker Thiel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-12-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001490&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001490&type=printable

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