Serum proteomics reveals high-affinity and convergent antibodies by tracking SARS-CoV-2 hybrid immunity to emerging variants of concern

Serum proteomics reveals high-affinity and convergent antibodies by tracking SARS-CoV-2 hybrid immunity to emerging variants of concern

The rapid spread of SARS-CoV-2 and its continuing impact on human health has prompted the need for effective and rapid development of monoclonal antibody therapeutics. In this study, we investigate polyclonal antibodies in serum and B cells from the whole blood of three donors with SARS-CoV-2 immuni...

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Bibliographic Details
Main Authors: Anand Patel, Thiago Lima, Richard Carson, Qiulong Huang, Stefano R. Bonissone, Natalie Castellana
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
mass spectrometry - LC-MS/MS
serum proteomics
monoclonal antibody
human-derived
next-generation sequencing (NGS)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509888/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509888/full

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