Retracing the path of evolution: polymorphisms of aspA codon 363 shape the fitness of Yersinia pestis

Retracing the path of evolution: polymorphisms of aspA codon 363 shape the fitness of Yersinia pestis

Yersinia pestis, the etiologic agent of plague, is a genetically monomorphic pathogen. By screening 1085 published Y. pestis genomes, we identified an unusual mutation hotspot within codon 363 of the aspartate ammonia-lyase gene aspA with at least six alleles in the population. Our investigation del...

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Main Authors: Kai Song, Ruichen Lv, Leiming Shen, Yarong Wu, Xiuwei Qian, Yiming Cui, Yumeng Wei, Yanbing Li, Yanting Zhao, Wenwu Yao, Yafang Tan, Yanping Han, Yujing Bi, Zongmin Du, Florent Sebbane, Yujun Cui, Ruifu Yang, Yajun Song
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Yersinia pestis
Aspa
polymorphism
competition
fitness
evolution
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2532700
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https://www.tandfonline.com/doi/10.1080/22221751.2025.2532700

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