Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids

Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids

Background: Photodynamic therapy (PDT) and radiotherapy using ionizing radiation (IR) are promising options for organ-preserving treatment of bladder cancer (BCa). A combination therapy (IR+PDT) could be beneficial for BCa treatment. Purpose: For PDT, we used the near-infrared photosensitizer tetrah...

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Bibliographic Details
Main Authors: Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Photodiagnosis and Photodynamic Therapy
Subjects:
Photodynamic therapy
Near-infrared photosensitizer
Ionizing radiation
Bladder cancer organoids
Multimodal, synergistic cytotoxicity
Immune cell invasion
Online Access:http://www.sciencedirect.com/science/article/pii/S1572100024004952
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