Decoding the Significance of Alpha Cell Function in the Pathophysiology of Type 1 Diabetes

Decoding the Significance of Alpha Cell Function in the Pathophysiology of Type 1 Diabetes

Alpha cells in the pancreas, traditionally known for their role in secreting glucagon to regulate blood glucose levels, are gaining recognition for their involvement in the pathophysiology of type 1 diabetes (T1D). In T1D, autoimmune destruction of beta cells results in insulin deficiency, which in...

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Main Authors: Jordan Carroll, Jessie Chen, Rahul Mittal, Joana R. N. Lemos, Mannat Mittal, Shreya Juneja, Amro Assayed, Khemraj Hirani
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
alpha cells
type 1 diabetes
glucose homeostasis
glucagon secretion
hypoglycemia
paracrine signaling
Online Access:https://www.mdpi.com/2073-4409/13/22/1914
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