Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts.

Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts.

Aging and pathophysiological conditions are linked to membrane changes which modulate membrane-controlled molecular switches, causing dysregulated heat shock protein (HSP) expression. HSP co-inducer hydroxylamines such as BGP-15 provide advanced therapeutic candidates for many diseases since they pr...

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Main Authors: Imre Gombos, Tim Crul, Stefano Piotto, Burcin Güngör, Zsolt Török, Gábor Balogh, Mária Péter, J Peter Slotte, Federica Campana, Ana-Maria Pilbat, Akos Hunya, Noémi Tóth, Zsuzsanna Literati-Nagy, László Vígh, Attila Glatz, Mario Brameshuber, Gerhard J Schütz, Andrea Hevener, Mark A Febbraio, Ibolya Horváth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028818&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028818&type=printable

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