Applying the layers of protection analysis (LOPA) method to high containment level biological facilities

Applying the layers of protection analysis (LOPA) method to high containment level biological facilities

Abstract The Layers of Protection Analysis (LOPA) method is a semi-quantitative risk assessment tool that is used to determine the ability of safeguards to protect against unplanned hazardous scenarios. One possible outcome of a LOPA is that existing and proposed safeguards are deemed sufficient to...

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Bibliographic Details
Main Authors: Andrian Harsono, Ryan Waters, Jason Tearle, Graeme Harkess
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
HAZOP
LOPA
Biocontainment
Safety Integrity Level
Safety instrumented function
Biosafety
Online Access:https://doi.org/10.1038/s41598-025-88546-8
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https://doi.org/10.1038/s41598-025-88546-8

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