Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling.

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling.

SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of the linear ubiquitin chain assembly complex (LUBAC). However, it is currently unclear how regulat...

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Main Authors: Nicola De Franceschi, Emilia Peuhu, Maddy Parsons, Sami Rissanen, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska, Jeroen Pouwels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0143423
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https://doi.org/10.1371/journal.pone.0143423

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