Identification and validation of a lenvatinib resistance-related prognostic signature in HCC, in which PFKFB4 contributes to tumor progression and lenvatinib resistance

Identification and validation of a lenvatinib resistance-related prognostic signature in HCC, in which PFKFB4 contributes to tumor progression and lenvatinib resistance

Abstract Background Drug resistance reflects the evolution of tumors and represents the leading factor behind recurrence and death. Lenvatinib is the first-line therapy for hepatocellular carcinoma (HCC), but its effectiveness is limited by rapid development of resistance. Therefore, we aimed to ide...

Full description

Saved in:
Bibliographic Details
Main Authors: Jinfeng Wang, Jianfei Shi, Lili Mi, Ning Li, Xin Han, Man Zhao, Xiaoling Duan, Guangjie Han, Jiaojiao Hou, Fei Yin
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Gastroenterology
Subjects:
Hepatocellular carcinoma
Lenvatinib resistance-related genes
Prognostic signature
Tumor microenvironment
Treatment response
Online Access:https://doi.org/10.1186/s12876-025-03861-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12876-025-03861-8

Similar Items