Baseline Factors Predictive of SLT Response: A Prospective Study
Purpose. To study the response to Selective Laser Trabeculoplasty (SLT) according to baseline medical treatment, angle pigmentation, age, diagnosis (open-angle glaucoma or ocular hypertension), and baseline intraocular pressure (IOP). Methods. 74 eyes of 74 patients were enrolled in this study. Bas...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/642869 |
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| _version_ | 1832545779669008384 |
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| author | Robin Bruen Mark R. Lesk Paul Harasymowycz |
| author_facet | Robin Bruen Mark R. Lesk Paul Harasymowycz |
| author_sort | Robin Bruen |
| collection | DOAJ |
| description | Purpose. To study the response to Selective Laser Trabeculoplasty (SLT) according to baseline medical treatment, angle pigmentation, age, diagnosis (open-angle glaucoma or ocular hypertension), and baseline intraocular pressure (IOP).
Methods. 74 eyes of 74 patients were enrolled in this study. Baseline characteristics were recorded for each patient. IOP in the treated and fellow eyes was measured at baseline, and 1 month, 6 months, and 12 months following SLT. IOP changes in the different groups were compared using two-way ANOVA and Pearson's correlation.
Results. The mean age of our cohort was 71±10 years. The mean baseline IOP was 21.5±5 mmHg, and the mean change in IOP from baseline in the treated eye at one year was −4.67±3.40 mmHg. Higher baseline IOP was highly correlated with greater absolute IOP decrease. Prostaglandin analogue use at baseline was shown to be associated with a statistically decreased IOP-lowering response following SLT when corrected for baseline IOP. No significant differences in IOP response were found when comparing groups stratified for age, angle pigmentation, phakic status, gender, or diagnosis.
Discussion. The results of this study confirm the finding that higher baseline IOP is a predictor of greater IOP response following SLT, and that pretreatment with prostaglandin analogue therapy is associated with a decreased IOP-lowering response following SLT. The study is limited by the small number of eyes with data available for complete case analysis. |
| format | Article |
| id | doaj-art-53cdf18caaaf4738a7612eaea48b281e |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-53cdf18caaaf4738a7612eaea48b281e2025-02-03T07:24:47ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/642869642869Baseline Factors Predictive of SLT Response: A Prospective StudyRobin Bruen0Mark R. Lesk1Paul Harasymowycz2Department of Ophthalmology, University of Montreal, Montreal, QC, CanadaDepartment of Ophthalmology, University of Montreal, Montreal, QC, CanadaDepartment of Ophthalmology, University of Montreal, Montreal, QC, CanadaPurpose. To study the response to Selective Laser Trabeculoplasty (SLT) according to baseline medical treatment, angle pigmentation, age, diagnosis (open-angle glaucoma or ocular hypertension), and baseline intraocular pressure (IOP). Methods. 74 eyes of 74 patients were enrolled in this study. Baseline characteristics were recorded for each patient. IOP in the treated and fellow eyes was measured at baseline, and 1 month, 6 months, and 12 months following SLT. IOP changes in the different groups were compared using two-way ANOVA and Pearson's correlation. Results. The mean age of our cohort was 71±10 years. The mean baseline IOP was 21.5±5 mmHg, and the mean change in IOP from baseline in the treated eye at one year was −4.67±3.40 mmHg. Higher baseline IOP was highly correlated with greater absolute IOP decrease. Prostaglandin analogue use at baseline was shown to be associated with a statistically decreased IOP-lowering response following SLT when corrected for baseline IOP. No significant differences in IOP response were found when comparing groups stratified for age, angle pigmentation, phakic status, gender, or diagnosis. Discussion. The results of this study confirm the finding that higher baseline IOP is a predictor of greater IOP response following SLT, and that pretreatment with prostaglandin analogue therapy is associated with a decreased IOP-lowering response following SLT. The study is limited by the small number of eyes with data available for complete case analysis.http://dx.doi.org/10.1155/2012/642869 |
| spellingShingle | Robin Bruen Mark R. Lesk Paul Harasymowycz Baseline Factors Predictive of SLT Response: A Prospective Study Journal of Ophthalmology |
| title | Baseline Factors Predictive of SLT Response: A Prospective Study |
| title_full | Baseline Factors Predictive of SLT Response: A Prospective Study |
| title_fullStr | Baseline Factors Predictive of SLT Response: A Prospective Study |
| title_full_unstemmed | Baseline Factors Predictive of SLT Response: A Prospective Study |
| title_short | Baseline Factors Predictive of SLT Response: A Prospective Study |
| title_sort | baseline factors predictive of slt response a prospective study |
| url | http://dx.doi.org/10.1155/2012/642869 |
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