AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy

AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy

Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer's disease (AD). Nevertheless, the development of brain-penetrant small-molecule Gal-3 inhibitors poses a significant challenge. To address this, we employed an artificial...

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Bibliographic Details
Main Authors: Xueyan Liu, Jiexin Xu, Shuping Zheng, Yaoyao Yang, Yuchong Xie, Jinyu Liu, Jian Zhong, Huiyao Zhang, Jiajing Chen, Chaoxian Dai, Dingyan Wang, Jiewei Luo, Xiaochun Chen, Feisheng Zhong, Zu-Cheng Ye
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Pharmacological Research
Subjects:
Galectin-3
Cognitive function
Alzheimer's disease
Neuroinflammation
Microglial activation
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002592
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http://www.sciencedirect.com/science/article/pii/S1043661825002592

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