Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease

Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease

The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson’s disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of disease-modifying treatments. The glymphatic sy...

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Bibliographic Details
Main Authors: Xiaoyue Lian, Zhenghao Liu, Zuobin Gan, Qingshan Yan, Luyao Tong, Linan Qiu, Yuntao Liu, Jiang-fan Chen, Zhihui Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-01-01
Series:Neural Regeneration Research
Subjects:
aquaporin-4
astrocytes
cerebrospinal fluid
glymphatic system
interstitial fluid
neurotoxic protein clearance
parkinson’s disease
perivascular spaces
sleep disturbance
α-synuclein
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00764
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https://journals.lww.com/10.4103/NRR.NRR-D-24-00764

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