Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals
Background. The present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA), and prolactin in patients with schizophrenia and healthy individuals. Method. A total of 100 patients with schizophrenia disorder (69 men and 31 women) and 190 healthy individuals (...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2016/3108689 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549376055050240 |
|---|---|
| author | Forough Riahi Maryam Izadi-mazidi Ali Ghaffari Elham Yousefi Shahram Khademvatan |
| author_facet | Forough Riahi Maryam Izadi-mazidi Ali Ghaffari Elham Yousefi Shahram Khademvatan |
| author_sort | Forough Riahi |
| collection | DOAJ |
| description | Background. The present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA), and prolactin in patients with schizophrenia and healthy individuals. Method. A total of 100 patients with schizophrenia disorder (69 men and 31 women) and 190 healthy individuals (94 men and 96 women) participated in this cross-sectional study. They were tested for hormone levels and completed demographic questionnaires. Data were analyzed using multivariate analysis of variance (MANOVA) and one-way analysis of variance. Results. Serum testosterone level was significantly higher in men with schizophrenia than in healthy men. Women with schizophrenia had a significantly higher level of testosterone and lower level of prolactin compared to healthy women. There were no significant differences in hormone levels across various subtypes of schizophrenia. No significant differences also were observed in hormones levels in patients with first-episode schizophrenia disorder compared to those in patients with recurrent episodes. Conclusion. This study indicated that abnormal testosterone and prolactin levels might be associated with pathophysiology of schizophrenia disorder. |
| format | Article |
| id | doaj-art-539e4c27786d4552baa1d1d70e5423c2 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-539e4c27786d4552baa1d1d70e5423c22025-02-03T06:11:31ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/31086893108689Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy IndividualsForough Riahi0Maryam Izadi-mazidi1Ali Ghaffari2Elham Yousefi3Shahram Khademvatan4Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Clinical Psychology, Faculty of Humanities, Shahed University, Tehran, IranDepartment of Medical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranCellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranBackground. The present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA), and prolactin in patients with schizophrenia and healthy individuals. Method. A total of 100 patients with schizophrenia disorder (69 men and 31 women) and 190 healthy individuals (94 men and 96 women) participated in this cross-sectional study. They were tested for hormone levels and completed demographic questionnaires. Data were analyzed using multivariate analysis of variance (MANOVA) and one-way analysis of variance. Results. Serum testosterone level was significantly higher in men with schizophrenia than in healthy men. Women with schizophrenia had a significantly higher level of testosterone and lower level of prolactin compared to healthy women. There were no significant differences in hormone levels across various subtypes of schizophrenia. No significant differences also were observed in hormones levels in patients with first-episode schizophrenia disorder compared to those in patients with recurrent episodes. Conclusion. This study indicated that abnormal testosterone and prolactin levels might be associated with pathophysiology of schizophrenia disorder.http://dx.doi.org/10.1155/2016/3108689 |
| spellingShingle | Forough Riahi Maryam Izadi-mazidi Ali Ghaffari Elham Yousefi Shahram Khademvatan Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals Scientifica |
| title | Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals |
| title_full | Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals |
| title_fullStr | Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals |
| title_full_unstemmed | Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals |
| title_short | Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals |
| title_sort | comparison of plasma neurosteroid and prolactin levels in patients with schizophrenia and healthy individuals |
| url | http://dx.doi.org/10.1155/2016/3108689 |
| work_keys_str_mv | AT foroughriahi comparisonofplasmaneurosteroidandprolactinlevelsinpatientswithschizophreniaandhealthyindividuals AT maryamizadimazidi comparisonofplasmaneurosteroidandprolactinlevelsinpatientswithschizophreniaandhealthyindividuals AT alighaffari comparisonofplasmaneurosteroidandprolactinlevelsinpatientswithschizophreniaandhealthyindividuals AT elhamyousefi comparisonofplasmaneurosteroidandprolactinlevelsinpatientswithschizophreniaandhealthyindividuals AT shahramkhademvatan comparisonofplasmaneurosteroidandprolactinlevelsinpatientswithschizophreniaandhealthyindividuals |