Rapid emergence of dolutegravir resistance on second-line dolutegravir-based ART

Rapid emergence of dolutegravir resistance on second-line dolutegravir-based ART

The integrase strand transfer inhibitor, dolutegravir (DTG), is widely used in first- and second-line antiretroviral therapy (ART) regimens in South Africa. We describe an adult with virological failure on second-line tenofovir/lamivudine/dolutegravir (TLD2) and rapid emergence of DTG resistance wit...

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Bibliographic Details
Main Authors: Kirusha Naidoo, Richard J. Lessells, Jienchi Dorward, Mahomed Y.S. Moosa, Yukteshwar Sookrajh, Pravi Moodley, Paul K. Drain, Nigel Garrett
Format: Article
Language:English
Published: AOSIS 2025-04-01
Series:Southern African Journal of HIV Medicine
Subjects:
drug resistance
dolutegravir resistance
drug-drug interaction
dolutegravir
rifapentine.
Online Access:https://sajhivmed.org.za/index.php/hivmed/article/view/1701
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https://sajhivmed.org.za/index.php/hivmed/article/view/1701

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