F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway

F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway

Abstract Background Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The latency-associated peptide (LAP) is essential for TGF-β1 activation. We previously constructed and prepared truncated LAP (tLAP), and confirmed that tLAP inhibited liv...

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Bibliographic Details
Main Authors: Zhiqin Cao, Keke Zhang, Jingruo Liu, Yu Pan, Jiayi Shi, Luxin Li, Xiaocan Sun, Shiqi Li, Xiaohuan Yuan, Dan Wu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Molecular Medicine
Subjects:
Skin fibrosis
TGF-β1
LAP
SPACE
EMT
Online Access:https://doi.org/10.1186/s10020-024-00815-w
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https://doi.org/10.1186/s10020-024-00815-w

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