Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype
LADA (latent autoimmune diabetes in adults) is a dual form of diabetes, combining the autoimmune features typical of type 1 diabetes and the clinical and metabolic aspects of type 2 diabetes. Due to the slow development of symptoms and often late age of onset, LADA is frequently misdiagnosed as typ...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57142 |
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| author | Maciej Wojszczyk Julia Kulbacka Karol Dziedzic Filip Arczewski Michalina Wójcikiewicz Marta Chuncia-Ileczko Julia Kacperczyk Witold Czyż Piotr Pasek Julia Ryniecka |
| author_facet | Maciej Wojszczyk Julia Kulbacka Karol Dziedzic Filip Arczewski Michalina Wójcikiewicz Marta Chuncia-Ileczko Julia Kacperczyk Witold Czyż Piotr Pasek Julia Ryniecka |
| author_sort | Maciej Wojszczyk |
| collection | DOAJ |
| description |
LADA (latent autoimmune diabetes in adults) is a dual form of diabetes, combining the autoimmune features typical of type 1 diabetes and the clinical and metabolic aspects of type 2 diabetes. Due to the slow development of symptoms and often late age of onset, LADA is frequently misdiagnosed as type 2 diabetes, which can lead to a delay in appropriate treatment. It is estimated that LADA affects between 4% and 12% of adults initially diagnosed with type 2 diabetes, making it a more common disease entity than previously thought. This paper examines current data on the epidemiology, pathogenesis, genetic factors and diagnostic criteria of LADA. Particular attention was given to the immunological and genetic aspects of the disease, which allow a more accurate differentiation of LADA from type 2 diabetes. The review also discusses the significance of early insulin therapy aimed at beta-cell preservation and the role of alternative treatments, such as DPP-4 inhibitors, which may influence disease progression. Diagnostic and therapeutic challenges stemming from the phenotypic similarities between LADA and type 2 diabetes are highlighted, along with potential benefits of early detection.
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| format | Article |
| id | doaj-art-53922221305b4326b0043896d5fa9302 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-53922221305b4326b0043896d5fa93022025-01-07T08:23:00ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57142Diagnosing and Managing LADA: A Review of the Overlooked Diabetes SubtypeMaciej Wojszczyk0https://orcid.org/0009-0002-8668-8821Julia Kulbacka1https://orcid.org/0009-0005-1181-9104Karol Dziedzic2https://orcid.org/0009-0007-8317-723XFilip Arczewski3https://orcid.org/0009-0008-5179-7255Michalina Wójcikiewicz4https://orcid.org/0009-0003-3671-1410Marta Chuncia-Ileczko5https://orcid.org/0009-0000-0913-9752Julia Kacperczyk6https://orcid.org/0009-0007-6354-301XWitold Czyż7https://orcid.org/0009-0006-4442-9900Piotr Pasek8https://orcid.org/0009-0001-6218-9887Julia Ryniecka9https://orcid.org/0009-0000-5937-9498University Clinical Hospital No. 1 of the Medical University of Lodz, ul. Kopcińskiego 22, 90-153 ŁódźCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandMedical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, Poland Medical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandMedical University of Lodz, Al. T. Kosciuszki 4, 90–419 Lodz, Poland Central Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandCopernicus Memorial Hospital, ul. Pabianicka 62, 93-513 Łódź, PolandMedical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, Poland LADA (latent autoimmune diabetes in adults) is a dual form of diabetes, combining the autoimmune features typical of type 1 diabetes and the clinical and metabolic aspects of type 2 diabetes. Due to the slow development of symptoms and often late age of onset, LADA is frequently misdiagnosed as type 2 diabetes, which can lead to a delay in appropriate treatment. It is estimated that LADA affects between 4% and 12% of adults initially diagnosed with type 2 diabetes, making it a more common disease entity than previously thought. This paper examines current data on the epidemiology, pathogenesis, genetic factors and diagnostic criteria of LADA. Particular attention was given to the immunological and genetic aspects of the disease, which allow a more accurate differentiation of LADA from type 2 diabetes. The review also discusses the significance of early insulin therapy aimed at beta-cell preservation and the role of alternative treatments, such as DPP-4 inhibitors, which may influence disease progression. Diagnostic and therapeutic challenges stemming from the phenotypic similarities between LADA and type 2 diabetes are highlighted, along with potential benefits of early detection. https://apcz.umk.pl/QS/article/view/57142LADA diabetesGADA antibodiestype 1 diabetestype 2 diabetesinsulin resistanceinsulin therapy |
| spellingShingle | Maciej Wojszczyk Julia Kulbacka Karol Dziedzic Filip Arczewski Michalina Wójcikiewicz Marta Chuncia-Ileczko Julia Kacperczyk Witold Czyż Piotr Pasek Julia Ryniecka Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype Quality in Sport LADA diabetes GADA antibodies type 1 diabetes type 2 diabetes insulin resistance insulin therapy |
| title | Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype |
| title_full | Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype |
| title_fullStr | Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype |
| title_full_unstemmed | Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype |
| title_short | Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype |
| title_sort | diagnosing and managing lada a review of the overlooked diabetes subtype |
| topic | LADA diabetes GADA antibodies type 1 diabetes type 2 diabetes insulin resistance insulin therapy |
| url | https://apcz.umk.pl/QS/article/view/57142 |
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