Pentoxifylline Enhances Sperm Quality, Reduces Oxidative Stress in Semen, and Decreases Sperm DNA Damage in Men with Asthenozoospermia Undergoing Assisted Reproductive Technology

Pentoxifylline Enhances Sperm Quality, Reduces Oxidative Stress in Semen, and Decreases Sperm DNA Damage in Men with Asthenozoospermia Undergoing Assisted Reproductive Technology

Oxidative stress (OS) contributes to poor sperm parameters and increased sperm DNA fragmentation (sDF), yet effective therapeutic strategies remain limited. This study aimed to evaluate the in vitro efficacy of pentoxifylline (PTX) in improving sperm motility and reducing OS and sDF in men with isol...

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Bibliographic Details
Main Authors: Oumaima Ammar, Marwa Ben Ali Gannoun, Tesnim Ajina, Assila Hadj Ali, Manel Boussabbeh, Amira Sallem, Zohra Haouas, Mariarosaria Di Tommaso, Meriem Mehdi
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Oxygen
Subjects:
asthenozoospermia
pentoxifylline
motility
viability
DNA damage
oxidative stress
Online Access:https://www.mdpi.com/2673-9801/5/2/8
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