Maternal loss of mouse Nlrp2 alters the transcriptome and DNA methylome in GV oocytes and impairs zygotic genome activation in embryos

Maternal loss of mouse Nlrp2 alters the transcriptome and DNA methylome in GV oocytes and impairs zygotic genome activation in embryos

Abstract Background NLRP2 is a subcortical maternal complex (SCMC) protein of mammalian oocytes and preimplantation embryos. SCMC proteins are encoded by maternal effect genes and play a pivotal role in the maternal-to-zygotic transition (MZT), early embryogenesis, and epigenetic (re)programming. Ma...

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Main Authors: Zahra Anvar, Michael D. Jochum, Imen Chakchouk, Momal Sharif, Hannah Demond, Alvin K. To, Daniel C. Kraushaar, Ying-Wooi Wan, Michael C. Mari, Simon Andrews, Gavin Kelsey, Ignatia B. Van den Veyver
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Clinical Epigenetics
Subjects:
Subcortical maternal complex
Oocyte
Imprinted genes
DNA methylation
Online Access:https://doi.org/10.1186/s13148-025-01889-x
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https://doi.org/10.1186/s13148-025-01889-x

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