Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends

Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends

<b>Background/Objectives:</b> This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability. Additionally, the study e...

Full description

Saved in:
Bibliographic Details
Main Authors: Rasha M. Elkanayati, Indrajeet Karnik, Prateek Uttreja, Nagarjuna Narala, Sateesh Kumar Vemula, Krizia Karry, Michael A. Repka
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
twin screw melt granulation
hot-melt extrusion
amorphous solid dispersion
Soluplus
Kollicoat IR
solubility enhancement
Online Access:https://www.mdpi.com/1999-4923/16/12/1630
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1999-4923/16/12/1630

Similar Items