Transcripts with high distal heritability mediate genetic effects on complex metabolic traits

Transcripts with high distal heritability mediate genetic effects on complex metabolic traits

Abstract Although many genes are subject to local regulation, recent evidence suggests that complex distal regulation may be more important in mediating phenotypic variability. To assess the role of distal gene regulation in complex traits, we combine multi-tissue transcriptomes with physiological o...

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Main Authors: Anna L. Tyler, J. Matthew Mahoney, Mark P. Keller, Candice N. Baker, Margaret Gaca, Anuj Srivastava, Isabela Gerdes Gyuricza, Madeleine J. Braun, Nadia A. Rosenthal, Alan D. Attie, Gary A. Churchill, Gregory W. Carter
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61228-9
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https://doi.org/10.1038/s41467-025-61228-9

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