Oral Delivery of miR146a Conjugated to Cerium Oxide Nanoparticles Improves an Established T Cell-Mediated Experimental Colitis in Mice

Oral Delivery of miR146a Conjugated to Cerium Oxide Nanoparticles Improves an Established T Cell-Mediated Experimental Colitis in Mice

<b>Background:</b> Dysregulated inflammation and oxidative stress are strongly implicated in the pathogenesis of inflammatory bowel disease. We have developed a novel therapeutic that targets inflammation and oxidative stress. It is comprised of microRNA-146a (miR146a)-loaded cerium oxid...

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Main Authors: Anisha Apte, Pujarini Dutta Dey, Srisaianirudh Reddy Julakanti, Monica Midura-Kiela, Stacy M. Skopp, Jimena Canchis, Tobias Fauser, James Bardill, Sudipta Seal, David M. Jackson, Fayez K. Ghishan, Pawel R. Kiela, Carlos Zgheib, Kenneth W. Liechty
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
inflammatory bowel disease
microRNA
nanomedicine
oxidative stress
Online Access:https://www.mdpi.com/1999-4923/16/12/1573
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