Silencing LY6K Suppresses CD44<sup>+</sup> EpCAM<sup>+</sup> HCT116 Human Colon Cancer Stem Cells Growth: Insights from In Vitro and In Vivo Evidence

Silencing LY6K Suppresses CD44<sup>+</sup> EpCAM<sup>+</sup> HCT116 Human Colon Cancer Stem Cells Growth: Insights from In Vitro and In Vivo Evidence

Lymphocyte antigen 6 complex, locus K (LY6K) is a putative oncogene in various human cancers, including colorectal cancer, where elevated expression is associated with poor prognosis. This study investigates the antitumor effects of LY6K in colon cancer stem cells (CCSCs) both in vitro and in vivo....

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Main Authors: Changhao Fu, Kuiqiao Chen, Jinyue Duan, Kun Liu, Miaomiao Li, Yuanyuan Chen, Zhongyi Cong, Yi Wang
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Current Issues in Molecular Biology
Subjects:
colon cancer
RNA interference
tumor growth
survival
LY6K
Online Access:https://www.mdpi.com/1467-3045/46/12/840
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