Emulating the EPIC trial using VetCompass primary-care data: causal effects of pimobendan in UK dogs with grade IV/VI heart murmurs.

Target trial emulation applies design principles from randomised controlled trials (RCTs) to the analysis of observational data, potentially replicating RCT results in real-world settings. The EPIC trial reported that pimobendan delays the onset of congestive heart failure (CHF) and extends survival...

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Bibliographic Details
Main Authors: Camilla Pegram, Karla Diaz-Ordaz, Dave C Brodbelt, Yu-Mei Chang, Adrian Boswood, Jenny Wilshaw, Carmen A T Reep, Sarah Balling, Jaya Sahota, David B Church, Dan G O'Neill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0325695
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