Role of CD133 antibody-conjugated nanocarrier in enhancing the targetability of hepatocellular carcinoma stem cells

Role of CD133 antibody-conjugated nanocarrier in enhancing the targetability of hepatocellular carcinoma stem cells

Abstract This study aimed at targeting hepatic cancer stem cells (CSCs) with quercetin (Q) or kaempferol (K) loaded into poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) decorated with CD133 antibody. For this purpose, the formulated Q NPs and K NPs and their free forms were evaluated for their...

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Bibliographic Details
Main Authors: Hadeer A. Aglan, Ahmed A. Abd-Rabou, Hanaa H. Ahmed, Ghada H. Elsayed, Mohamed S. Kishta, Manar A. Elhinnawi, Nadia S. Mahmoud
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Hepatic cancer stem cells
CD133
PLGA nanoparticles
Quercetin
Kaempferol
Online Access:https://doi.org/10.1038/s41598-025-14435-9
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https://doi.org/10.1038/s41598-025-14435-9

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