Neuroprotective effects of Gastrodia elata Blume on promoting M2 microglial polarization by inhibiting JNK/TLR4/T3JAM/NF-κB signaling after transient ischemic stroke in rats

Neuroprotective effects of Gastrodia elata Blume on promoting M2 microglial polarization by inhibiting JNK/TLR4/T3JAM/NF-κB signaling after transient ischemic stroke in rats

BackgroundGastrodia elata Blume, also called Tian Ma (TM), has been used to treat stroke for centuries. However, its effects on inflammation in acute cerebral ischemic injury and underlying mechanisms involved in microglial polarization remain unknown. The present study explored the effects of the T...

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Bibliographic Details
Main Authors: Shang-Chih Huang, Hui-Chi Huang, Wen-Ling Liao, Shung-Te Kao, Chin-Yi Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
Gastrodia elata Blume
cerebral ischemia
C-Jun N-terminal kinase
toll-like receptor 4
TRAF3-interacting JNK-activating modulator
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1469602/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1469602/full

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