Development and validation of hierarchical signature for precision individualized therapy based on the landscape associated with necroptosis in clear cell renal cell carcinoma

BackgroundIncreasing evidence is showing that necroptosis has unique clinical significance in the occurrence and development of multiple diseases. Here, we systematically evaluate the role of necroptosis in clear cell renal cell carcinoma (ccRCC) and analyze its regulatory patterns.MethodsFirst, we...

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Bibliographic Details
Main Authors: Gao-Sheng Yao, Jun-Shang Dai, Liang-Min Fu, Juan Lin, Zhi-Ping Tan, Lei Dai, Wei Chen, Jun-Hang Luo, Jin-Huan Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1470145/full
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