<i>ERCC1</i> and <i>ERCC2</i> Polymorphisms Predict the Efficacy and Toxicity of Platinum-Based Chemotherapy in Small Cell Lung Cancer

<i>ERCC1</i> and <i>ERCC2</i> Polymorphisms Predict the Efficacy and Toxicity of Platinum-Based Chemotherapy in Small Cell Lung Cancer

Standard first-line chemotherapy in small cell lung cancer (SCLC) is based on the platinum plus etoposide combination. Despite a high objective response rate, responses are not durable and chemotherapy-induced toxicity may compromise treatment. Genetic variants in genes involved in the DNA-repair pa...

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Bibliographic Details
Main Authors: Andrés Barba, Laura López-Vilaró, Malena Ferre, Margarita Majem, Sergio Martinez-Recio, Olga Bell, María J. Arranz, Juliana Salazar, Ivana Sullivan
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Pharmaceutics
Subjects:
<i>ERCC1</i>
<i>ERCC2</i>
platinum-based chemotherapy
small cell lung cancer
pharmacogenomics
Online Access:https://www.mdpi.com/1999-4923/16/9/1121
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https://www.mdpi.com/1999-4923/16/9/1121

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