Cilengitide sensitivity is predicted by overall integrin expression in breast cancer

Cilengitide sensitivity is predicted by overall integrin expression in breast cancer

Abstract Background Treatment options for triple-negative breast cancer (TNBC) are limited and patients face a poor prognosis. Here, we sought to identify drugs that target TNBC vulnerabilities and understand the biology underlying these responses. We analyzed the Broad Institute DepMap to identify...

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Bibliographic Details
Main Authors: Nomeda Girnius, Aylin Z. Henstridge, Benjamin Marks, Jeffrey K. Yu, G. Kenneth Gray, Chris Sander, Ioannis K. Zervantonakis, Augustin Luna
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Triple negative breast cancer
Integrins
Proteomics
Extracellular matrix
Drug screening
Online Access:https://doi.org/10.1186/s13058-024-01942-2
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https://doi.org/10.1186/s13058-024-01942-2

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