Spider venom peptides with unique fold selectively block Shaker-type potassium channels

Spider venom peptides with unique fold selectively block Shaker-type potassium channels

Abstract Natural toxins are highly effective at targeting ion channels with high selectivity and potency. To date, all identified spider venom peptide toxins that modulate voltage-gated potassium (KV) channels inhibit Shab (KV2) or Shal-related isoforms (KV4) by interacting with their voltage-sensin...

Full description

Saved in:
Bibliographic Details
Main Authors: Alexey I. Kuzmenkov, Valentina A. Iunusova, Vladislav A. Lushpa, Yakov A. Deyev, Vladislav V. Babenko, Daniil V. Osipov, Antonina A. Berkut, Jan Tytgat, Eduard V. Bocharov, David J. Adams, Rocio K. Finol-Urdaneta, Alexander A. Vassilevski
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cellular and Molecular Life Sciences
Subjects:
Ion channel
Neurotoxin
Blocker
Spatial structure
Inhibitor cystine knot
Disulfide
Online Access:https://doi.org/10.1007/s00018-025-05778-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1007/s00018-025-05778-7

Similar Items